• When I first learned about DNA, I was fascinated with the question of how a compound with such simplicity could give us all the diversity we see in the world. It was with that question in mind that I chose to venture into biochemistry. After completing my undergraduate degree in 生物化学 here at 澳门金沙线上赌博官网, I went on to obtain a doctoral degree in 摩尔ecular Biophysics at the Johns Hopkins University with David E. 德雷伯. I then crossed the country to San Francisco for a postdoctoral fellowship at University of California, San Francisco with Christine Guthrie. Each experience brought me a new set of tools to approach my questions, which had only grown in complexity with the more I learned. 一路走来, I was also continually reminded how much I loved the interplay between teaching and research. Therefore, I sought out positions where teaching and research were partnered. This brought me back to Texas, and ultimately to 澳门金沙线上赌博官网.

    • Ph.D. in 摩尔ecular Biophysics, John Hopkins University
    • B.S. in 生物化学、 圣澳门金沙赌城线上游戏 
    • C.C. Schreib E.K. 鲍曼,C.A. 埃尔南德斯,.L. 卢卡斯,C.H.S. C. maed. (2018) Functional and 物化学ical Characterization of Dib1’s Role in Splicing, Journal of 摩尔ecular 医学杂志ogy, 430(11): 1640-1651.
    • A. Gujjari B.V. 罗德里格斯,J. Pescador C. maed G.W. 比尔和L.K. 刘易斯(2018) Factors affecting the association of single- and double-stranded RNAs with montmorillonite nanoclays, International Journal of 医学杂志ogical Macromolecules, 109:551-559.
    • B.V. 罗德里格斯,E.T. Malczewskyj J.M. Cabiya L.K. 刘易斯和C. maed (2016) Identification of RNase-resistant RNAs in Saccharomyces cerevisiae extracts: separation from chromosomal DNA by selective precipitation. 分析的. 物化学. 492, 69-75.
    • B.V. 罗德里格斯,J. Pescador N.Pollok G.W. 比尔,C. 梅德尔和L. K. 刘易斯(2015). 尺寸的影响, secondary structure and counterions on the binding of small RNAs to layered double hydroxide nanoparticles. Biointerphases. 10(4): 041007.
    • J. 阿贝尔森,M. 布兰科,M.A. Ditzler F. Fuller, P. Aravamudhan, M. 木材、T. 别墅,维.E. 瑞安,我.A. Pleiss C. maed C. 格思里,N.G. 沃尔特(2010). Conformational Dynamics of single pre-mRNA molecules during 在体外 拼接. Nat. 结构体. 摩尔. 医学杂志. 17(4): 504-512.
    • L. 张,T. 徐,C. maed L. 芽,J. 小腿,J. 拒绝,C. 格思里,J.A. 请，还有R. Zhao (2009) 结构体ural Evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2.  Nat. 结构体. 摩尔. 医学杂志. 16(7): 731-739.
    • C. maed *,.K. Kutach*和C. 格思里(2009). ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 Helicase requires the C-terminus of Prp8. Nat. 结构体. 摩尔. 医学杂志. 16(1): 42-8.  *equal contributions.
    • C. maed G.L. Conn, and D.E. 德雷伯(2006). Optimization of a Ribosomal 结构体ural Domain by Natural Selection. 生物化学、 45(21): 6635-43.
    • C. 麦德和D.E. 德雷伯(2005). A small protein unique to bacteria organizes rRNA tertiary structure over an extensive region of the 50S ribosomal subunit. J. 摩尔. 医学杂志., 354 (2): 436-46.

    研究 in the maed Lab centers on characterizing a key mechanism in gene expression, pre-messenger RNA 拼接.  Splicing precisely removes non-protein coding sequences from RNA prior to translation into proteins. The mechanism involves large-scale rearrangements of protein-RNA complexes, which must be regulated to ensure both 拼接 timing and accuracy. Our current work focuses on identifying the mechanisms by which several essential 拼接 proteins regulate spliceosome assembly and activation.  We use a variety of biochemical, molecular biological, and genetics techniques to dissect the importance of protein-nucleic acid and protein-protein interactions in the spliceosome.

    • 普通化学 
    • 生物化学